Department of Applied Chemistry & Chemical Engineering

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Home>About Us>Chairman>Academic Staff>Dr. M. Taufiq Alam

 

Contact Information

Professor Department of Applied Chemistry and Chemical Engineering Room No. #241, 2nd Science Building, University of Rajshahi, Rajshahi-6205, Bangladesh Tel: +(880) 721-750041 Ext. 4106 (off)         +(880) 721-773832 (res)                                              +(880) 1715-138813 (mobile) Fax: +(880) 721-750064 e-mail: talam@ru.ac.bd

Research Area & Research Interest

Research Area

Single Molecule force spectroscopy

Research Interest

Understanding the network of various types of intramolecular forces that are intemately related to the stabilization of protein structure is a challenging task in molecular and structure biology but it will eventually lead us to elucidate the way the tertiary structure of a proteins is formed. Such intramolecular forces result from a multiple weak, non-covalent bonds formed within the molecule. They stabilize the secondary and tertiary structures of biological macromolecules, and structures determine the spatial variation and magnitude of forces that control the interaction of proteins.

 

List of Publications

1.	Afrin, R., Alam, M.T., and Ikai, A.,  Pre-transition and Progressive Softening of Bovine Carbonic Anhydrase II as Probed by Single Molecule Atomic Force Microscopy Protein Science 14: 1447--1457 (2005).
2.	Ohta S., Alam, M.T. and Ikai, A. Origin of mechanical strength of bovine carbonic anhydrase studied by molecular dynamics simulation. Biophys. J. 87(6):4007-20 (2004).
3.	Okajima, T., Arakawa, H., Alam, M.T., Sekiguchi, H. and Ikai, A., Dynamics of a partially stretched protein molecule studied using an atomic force microscope. Biophys Chem 107: 51 –61 (2004).
4.	Ikai,A., Afrin, R., Hertadi, R., Sekiguchi, H., Kim, H., Uehara, H., Wang, T., Alam, M.T., Arakawa, H. and Osada, T., Nano-mechanics of protein molecules and cellular structures  Recent Res. Devel. Applied Physics. (2003) 6 717-732.
5.	Ikai, A., Afrin, R., Sekiguchi, H., Okajima, T., Alam, M.T. and Nishida, S., Nano-mechanical methods in biochemistry using atomic force microscopy.. Current Protein and Polypeptide Science, 4(3): 181-193 (2003).
6.	Alam, M.T., Yamada, T., Carlsson, U. and Ikai, A., The importance of being knotted: Effects of C-terminal knot structure on enzymatic and mechanical properties of bovine carbonic anhydrase II. FEBS Letters 519(1-3): 35-40 (2002). (our figure featured in the cover page of the journal)
7.	Ikai, A., Idris, A. Wang, T., Alam, M.T., Afrin, R., Hyonchol, K., Sekiguchi, H., Arakawa,  H. and Osada, T. Nanotechnology and Protein Mechanism. J. of Biological Physics 28: 561-572 (2002).
8.	Hasan, M.F., Molla, A.H., Ahsan, M.S. and Alam, M.T. Physicochemical properties and fatty acid distribution pattern in lipids of Eutropiichthys vacha Hamilton-buchanan (family schilbeidae).  PJBS. 5(6): 696-698 (2002).
9.	Kashiwagi, A., Noumachi, W., Katsuno, M., Alam, M.T., Urabe, I. and Yomo, T., "Plasticity of fitness and diversification process during an experimental molecular evolution" J Mol Evol 52(6):502-9 (2001). (best paper awared)
10.	Alam, M.T. and Ikai, A. Protein stretching V: two forms of carbonic dehydratase detected by force microscopy. Applied Physics A 72:121-124 (2001).
11.	Idiris A, Alam M.T, Ikai A., Spring mechanics of alpha-helical polypeptide Protein Engineering (2000) 13(11):763-70. (cover page of the journal used our figure.)